Intermittent nesiritide therapy in outpatients with chronic heart failure
نویسندگان
چکیده
منابع مشابه
Nesiritide in acute decompensated heart failure.
To the Editor: In an editorial accompanying an article by O’Connor et al.1 on the effect of nesiritide in patients with acute decompensated heart failure (July 7 issue), Topol2 describes the meandering path of nesiritide from approval by the Food and Drug Administration (FDA) on the basis of limited data through an ultimately disappointing pivotal trial. This discussion of the unfortunate legac...
متن کاملBiomarker responses during and after treatment with nesiritide infusion in patients with decompensated chronic heart failure.
BACKGROUND Objective methods to assess the adequacy of medication therapy for patients with advanced heart failure are lacking. Serial measurements of biomarkers might be beneficial. Therapy guided by N-terminal pro-B-type natriuretic peptide (NT-proBNP) might be helpful because NT-proBNP should be lowered by therapies that decrease endogenous BNP secretion. METHODS NT-proBNP and BNP were mea...
متن کاملgalectin-۳ serum levels are independently associated with microalbuminuria in chronic heart failure outpatients
results among the patients enrolled, 61 had microalbuminuria (uacr, 30-299) and 133 normoalbuminuria (uacr, < 30). patients with normoalbuminuria showed significantly higher levels of gal-3 than those without (19.9 ± 8.8 vs. 14.6 ± 5.5 ng/ml). the stepwise regression analysis indicated that gal-3 was the first determinant of microalbuminuria (odds ratio [or]: 1.08; 95% confidence interval [ci]:...
متن کاملNesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine
Background—Nesiritide (synthetic human brain natriuretic peptide) is approved for the treatment of symptomatic heart failure. However, studies of brain natriuretic peptide in patients with heart failure have come to conflicting conclusions about effects on glomerular filtration rate (GFR), effective renal plasma flow, natriuresis, and diuresis. Methods and Results—To identify a population at hi...
متن کاملNesiritide as an adjunctive therapy in adult patients with heart failure undergoing high-risk cardiac surgery.
Patients and Methods Between October 2003 and January 2004, a total of 12 patients with advanced heart failure underwent cardiac surgery by a single surgeon (L.E.S.) at a single center. The use of nesiritide was determined by 4 intraoperative criteria: (1) congestive heart failure (New York Heart Association functional class III-IV), (2) pulmonary hypertension (systolic pulmonary arterial press...
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ژورنال
عنوان ژورنال: American Journal of Health-System Pharmacy
سال: 2005
ISSN: 1079-2082,1535-2900
DOI: 10.1093/ajhp/62.2.196